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In this book Harris argues that science can establish universal values cross-culturally, and claims that the "is-ought" distinction is a needless constraint on human thought. After reading this book, I agree. Harris argues from intellectual authority - his end-notes eat up approximately 40 pages, as does his bibliography. Even the end notes are interesting to read.
Also interesting are his descriptions of how our moral intuitions often fail us. He details the bizarre and troubling "genocide neglect" phenomenon, and regales us with the always interesting philosophical trolley problems. If a god does provide us with our moral intuitions, then she's has a weird sense of humor.
Beware the section on psychopathy, as Harris leaves little unsaid. It is not gratuitous, but it is detailed, and it gave me nightmares.
Even though some of the subject matter is difficult, there is a reason to hope: i.e. we can jettison relativism and the dogma of religion. Harrison articulates difficult concepts clearly and without needless jargon. And while this is not the final word on this subject, it's a great beginning.
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